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norskBlar i forfatter "Olsen, Randi"
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Elevated Plasma Levels of P‐Selectin Glycoprotein Ligand‐1 Positive Microvesicles in Patients with Unprovoked Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-31)Background<br> Microvesicles (MVs) express antigens from their parental cells and have a highly procoagulant surface. Animal studies suggest that P‐Selectin Glycoprotein Ligand‐1 positive (PSGL‐1+) MVs play a role in the pathogenesis of venous thromboembolism (VTE).<p> Objective<br> The aim of this study was to determine plasma levels, the cellular origin and the morphological characteristics ... -
High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-05)Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ... -
Human endogenous retrovirus W Activity in cartilage of osteoarthritis patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Impact of preanalytical conditions on plasma concentration and size distribution of extracellular vesicles using Nanoparticle Tracking Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-21)Optimal pre-analytical handling is essential for valid measurements of plasma concentration and size distribution of extracellular vesicles (EVs). We investigated the impact of plasma preparation, various anticoagulants (Citrate, EDTA, CTAD, Heparin), and fasting status on concentration and size distribution of EVs measured by Nanoparticle Tracking Analysis (NTA). Blood was drawn from 10 healthy ... -
Kliniske studier av av yrkesbetinget løsemiddeleksponerte. Et systematisk litteratursøk
(Research report; Forskningsrapport, 2009)I Norge er det enighet om de overordnede kriteriene for å gi diagnosen løsemiddelskade. Likevel er det ikke utviklet en enhetlig og detaljert modell for utredning av slik skade. Nasjonalt kunnskapssenter for helsetjenesten har i samarbeid med de norske utredningsmiljøene for løsemiddelskade gjennomført et litteratursøk etter kliniske studier av personer med langvarig yrkesbetinget løsemiddeleksponering. ... -
Liver sinusoidal endothelial cells represents an important blood clearance system in pigs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2003-01-03)Background: Numerous studies in rats and a few other mammalian species, including man, have shown that the sinusoidal cells constitute an important part of liver function. In the pig, however, which is frequently used in studies on liver transplantation and liver failure models, our knowledge about the function of hepatic sinusoidal cells is scarce. We have explored the scavenger function of pig ... -
No significant histological or ultrastructural tendinosis changes in the hamsting tendon in patients with mild to moderate osteoarthritis of the knee?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-20)Purpose To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> Methods Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with mild ... -
No significant histological or ultrastructural tendinosis changes in the hamstring tendon in patients with mild to moderate osteoarthritis of the knee?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)Purpose - To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> <p>Methods - Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with ... -
Photonic-chip assisted correlative light and electron microscopy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-07)Correlative light and electron microscopy (CLEM) unifies the versatility of light microscopy (LM) with the high resolution of electron microscopy (EM), allowing one to zoom into the complex organization of cells. Here, we introduce photonic chip assisted CLEM, enabling multi-modal total internal reflection fluorescence (TIRF) microscopy over large field of view and high precision localization of the ... -
Stimulation of exosome release by extracellular DNA is conserved across multiple cell types
(Journal article; Tidsskriftartikkel; Manuskript; Peer reviewed; Preprint, 2018-06-28)Exosomes are distinguished from other types of extracellular vesicles by their small and relatively uniform size (30-100 nm) and their composition which reflects their endo-lysosomal origin. Involvement of these extracellular organelles in intercellular communication and their implication in pathological conditions has fuelled intensive research on mammalian exosomes; however, currently, very little ...
